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Infection and Immunity, July 1999, p. 3637-3640, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Enhanced In Vivo Immune Responses to Bacterial Lipopolysaccharide by Exogenous CD40 Stimulation

Tom A. Barr, and Andrew W. Heath*

Division of Molecular and Genetic Medicine, University of Sheffield Medical School, Sheffield, United Kingdom

Received 8 February 1999/Returned for modification 24 March 1999/Accepted 15 April 1999

The lack of specific T-cell help in immune responses to thymus-independent antigens results in weak, predominantly immunoglobulin M-mediated immunity with little or no memory. In the work presented here we show how the exogenous stimulation of CD40 by monoclonal antibodies can mimic T-cell help, resulting in enhanced immune responses which are protective against bacterial infection.

* Corresponding author. Mailing address: Division of Molecular and Genetic Medicine, F-Floor, University of Sheffield Medical School, Beech Hill Rd., Sheffield, S10 2RX, United Kingdom. Phone: (44) 114 271 3516. Fax: (44) 114 273 9926. E-mail: a.w.heath{at}shef.ac.uk.

Infection and Immunity, July 1999, p. 3637-3640, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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