This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Julia, V.
Right arrow Articles by Glaichenhaus, N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Julia, V.
Right arrow Articles by Glaichenhaus, N.

 Previous Article  |  Next Article 

Infection and Immunity, July 1999, p. 3641-3644, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

CD4+ T Cells Which React to the Leishmania major LACK Antigen Rapidly Secrete Interleukin-4 and Are Detrimental to the Host in Resistant B10.D2 Mice

Valérie Julia, and Nicolas Glaichenhaus*

Institut de Pharmacologie Moléculaire et Cellulaire, 06560 Valbonne, France

Received 16 February 1999/Returned for modification 19 March 1999/Accepted 14 April 1999

Leishmania major induces the rapid production of interleukin-4 (IL-4) in both susceptible BALB/c and resistant B10.D2 mice. In both strains, IL-4 is produced by T cells which react to the parasite LACK (for Leishmania homolog of the receptor for activated C kinase) antigen. The rapid production of IL-4 in B10.D2 mice does not confer susceptibility but results in increased parasite burdens.

* Corresponding author. Mailing address: Institut de Pharmacologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Groupement de Recherche en Parasitologie (GDR), 660 Route des Lucioles, 06560 Valbonne, France. Phone: 33 4 93 95 77 85. Fax: 33 4 93 95 77 08. E-mail: glaichenhaus{at}ipmc.cnrs.fr.

Infection and Immunity, July 1999, p. 3641-3644, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Benhnini, F., Chenik, M., Laouini, D., Louzir, H., Cazenave, P. A., Dellagi, K. (2009). Comparative Evaluation of Two Vaccine Candidates against Experimental Leishmaniasis Due to Leishmania major Infection in Four Inbred Mouse Strains. CVI 16: 1529-1537 [Abstract] [Full Text]  
  • Liu, D., Kebaier, C., Pakpour, N., Capul, A. A., Beverley, S. M., Scott, P., Uzonna, J. E. (2009). Leishmania major Phosphoglycans Influence the Host Early Immune Response by Modulating Dendritic Cell Functions. Infect. Immun. 77: 3272-3283 [Abstract] [Full Text]  
  • Suzue, K., Kobayashi, S., Takeuchi, T., Suzuki, M., Koyasu, S. (2008). Critical role of dendritic cells in determining the Th1/Th2 balance upon Leishmania major infection. Int Immunol 20: 337-343 [Abstract] [Full Text]  
  • Babay, B. E. C., Louzir, H., Kebaier, C., Boubaker, S., Dellagi, K., Cazenave, P.-A. (2004). Inbred Strains Derived from Feral Mice Reveal New Pathogenic Mechanisms of Experimental Leishmaniasis Due to Leishmania major. Infect. Immun. 72: 4603-4611 [Abstract] [Full Text]  
  • Iwasaki, A. (2003). The Importance of CD11b+ Dendritic Cells in CD4+ T Cell Activation In Vivo: With Help from Interleukin 1. JEM 198: 185-190 [Full Text]  
  • Coelho, E. A. F., Tavares, C. A. P., Carvalho, F. A. A., Chaves, K. F., Teixeira, K. N., Rodrigues, R. C., Charest, H., Matlashewski, G., Gazzinelli, R. T., Fernandes, A. P. (2003). Immune Responses Induced by the Leishmania (Leishmania) donovani A2 Antigen, but Not by the LACK Antigen, Are Protective against Experimental Leishmania (Leishmania) amazonensis Infection. Infect. Immun. 71: 3988-3994 [Abstract] [Full Text]  
  • Lang, T., Courret, N., Colle, J.-H., Milon, G., Antoine, J.-C. (2003). The Levels and Patterns of Cytokines Produced by CD4 T Lymphocytes of BALB/c Mice Infected with Leishmania major by Inoculation into the Ear Dermis Depend on the Infectiousness and Size of the Inoculum. Infect. Immun. 71: 2674-2683 [Abstract] [Full Text]  
  • MAALEJ, I. A., CHENIK, M., LOUZIR, H., BEN SALAH, A., BAHLOUL, C., AMRI, F., DELLAGI, K. (2003). COMPARATIVE EVALUATION OF ELISAS BASED ON TEN RECOMBINANT OR PURIFIED LEISHMANIA ANTIGENS FOR THE SERODIAGNOSIS OF MEDITERRANEAN VISCERAL LEISHMANIASIS. Am J Trop Med Hyg 68: 312-320 [Abstract] [Full Text]  
  • Launois, P., Gumy, A., Himmelrich, H., Locksley, R. M., Rocken, M., Louis, J. A. (2002). Rapid IL-4 Production by Leishmania Homolog of Mammalian RACK1-Reactive CD4+ T Cells in Resistant Mice Treated Once with Anti-IL-12 or -IFN-{gamma} Antibodies at the Onset of Infection with Leishmania major Instructs Th2 Cell Development, Resulting in Nonhealing Lesions. J. Immunol. 168: 4628-4635 [Abstract] [Full Text]  
  • Melby, P. C., Yang, J., Zhao, W., Perez, L. E., Cheng, J. (2001). Leishmania donovani p36(LACK) DNA Vaccine Is Highly Immunogenic but Not Protective against Experimental Visceral Leishmaniasis. Infect. Immun. 69: 4719-4725 [Abstract] [Full Text]  
  • Schilling, S., Glaichenhaus, N. (2001). T Cells That React to the Immunodominant Leishmania major LACK Antigen Prevent Early Dissemination of the Parasite in Susceptible BALB/c Mice. Infect. Immun. 69: 1212-1214 [Abstract] [Full Text]  
  • Julia, V., McSorley, S. S., Malherbe, L., Breittmayer, J.-P., Girard-Pipau, F., Beck, A., Glaichenhaus, N. (2000). Priming by Microbial Antigens from the Intestinal Flora Determines the Ability of CD4+ T Cells to Rapidly Secrete IL-4 in BALB/c Mice Infected with Leishmania major. J. Immunol. 165: 5637-5645 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»