This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Riggle, P. J.
Right arrow Articles by Kumamoto, C. A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Riggle, P. J.
Right arrow Articles by Kumamoto, C. A.

 Previous Article  |  Next Article 

Infection and Immunity, July 1999, p. 3649-3652, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Invasive Lesions Containing Filamentous Forms Produced by a Candida albicans Mutant That Is Defective in Filamentous Growth in Culture

Perry J. Riggle,1 Karl A. Andrutis,2 Xi Chen,1 Saul R. Tzipori,2 and Carol A. Kumamoto1,*

Department of Molecular Biology and Microbiology, Tufts University School of Medicine, Boston, Massachusetts 02111,1 and Division of Infectious Diseases, Tufts University School of Veterinary Medicine, North Grafton, Massachusetts 015362

Received 2 February 1999/Returned for modification 21 March 1999/Accepted 14 April 1999

A Candida albicans efg1 cph1 double mutant is nonfilamentous under standard laboratory conditions and avirulent in mice. However, this mutant produced filaments in the tongues of immunosuppressed gnotobiotic piglets and when embedded in agar, demonstrating that an Efg1p- and Cph1p-independent pathway for promotion of filamentous growth exists.

* Corresponding author. Mailing address: Department of Molecular Biology and Microbiology, Tufts University, 136 Harrison Ave., Boston, MA 02111. Phone: (617) 636-0404. Fax: (617) 636-0337. E-mail: ckumamot{at}opal.tufts.edu.

Infection and Immunity, July 1999, p. 3649-3652, Vol. 67, No. 7
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Balish, E. (2009). A URA3 null mutant of Candida albicans (CAI-4) causes oro-oesophageal and gastric candidiasis and is lethal for gnotobiotic, transgenic mice (Tg{epsilon}26) that are deficient in both natural killer and T cells. J Med Microbiol 58: 290-295 [Abstract] [Full Text]  
  • Westwater, C., Balish, E., Warner, T. F., Nicholas, P. J., Paulling, E. E., Schofield, D. A. (2007). Susceptibility of gnotobiotic transgenic mice (Tg{epsilon}26) with combined deficiencies in natural killer cells and T cells to wild-type and hyphal signalling-defective mutants of Candida albicans. J Med Microbiol 56: 1138-1144 [Abstract] [Full Text]  
  • Biswas, S., Van Dijck, P., Datta, A. (2007). Environmental Sensing and Signal Transduction Pathways Regulating Morphopathogenic Determinants of Candida albicans. Microbiol. Mol. Biol. Rev. 71: 348-376 [Abstract] [Full Text]  
  • Eisman, B., Alonso-Monge, R., Roman, E., Arana, D., Nombela, C., Pla, J. (2006). The Cek1 and Hog1 Mitogen-Activated Protein Kinases Play Complementary Roles in Cell Wall Biogenesis and Chlamydospore Formation in the Fungal Pathogen Candida albicans. Eukaryot Cell 5: 347-358 [Abstract] [Full Text]  
  • Cao, F., Lane, S., Raniga, P. P., Lu, Y., Zhou, Z., Ramon, K., Chen, J., Liu, H. (2006). The Flo8 Transcription Factor Is Essential for Hyphal Development and Virulence in Candida albicans. Mol. Biol. Cell 17: 295-307 [Abstract] [Full Text]  
  • Richard, M. L., Nobile, C. J., Bruno, V. M., Mitchell, A. P. (2005). Candida albicans Biofilm-Defective Mutants. Eukaryot Cell 4: 1493-1502 [Abstract] [Full Text]  
  • Kumamoto, C. A. (2005). A contact-activated kinase signals Candida albicans invasive growth and biofilm development. Proc. Natl. Acad. Sci. USA 102: 5576-5581 [Abstract] [Full Text]  
  • Balish, E., Warner, T. F., Nicholas, P. J., Paulling, E. E., Westwater, C., Schofield, D. A. (2005). Susceptibility of Germfree Phagocyte Oxidase- and Nitric Oxide Synthase 2-Deficient Mice, Defective in the Production of Reactive Metabolites of Both Oxygen and Nitrogen, to Mucosal and Systemic Candidiasis of Endogenous Origin. Infect. Immun. 73: 1313-1320 [Abstract] [Full Text]  
  • vandenBerg, A. L., Ibrahim, A. S., Edwards, J. E. Jr., Toenjes, K. A., Johnson, D. I. (2004). Cdc42p GTPase Regulates the Budded-to-Hyphal-Form Transition and Expression of Hypha-Specific Transcripts in Candida albicans. Eukaryot Cell 3: 724-734 [Abstract] [Full Text]  
  • Korting, H. C., Hube, B., Oberbauer, S., Januschke, E., Hamm, G., Albrecht, A., Borelli, C., Schaller, M. (2003). Reduced expression of the hyphal-independent Candida albicans proteinase genes SAP1 and SAP3 in the efg1 mutant is associated with attenuated virulence during infection of oral epithelium. J Med Microbiol 52: 623-632 [Abstract] [Full Text]  
  • Newport, G., Kuo, A., Flattery, A., Gill, C., Blake, J. J., Kurtz, M. B., Abruzzo, G. K., Agabian, N. (2003). Inactivation of Kex2p Diminishes the Virulence of Candida albicans. J. Biol. Chem. 278: 1713-1720 [Abstract] [Full Text]  
  • Lewis, R. E., Lo, H.-J., Raad, I. I., Kontoyiannis, D. P. (2002). Lack of Catheter Infection by the efg1/efg1cph1/cph1 Double-Null Mutant, a Candida albicans Strain That Is Defective in Filamentous Growth. Antimicrob. Agents Chemother. 46: 1153-1155 [Abstract] [Full Text]  
  • Giusani, A. D., Vinces, M., Kumamoto, C. A. (2002). Invasive Filamentous Growth of Candida albicans Is Promoted by Czf1p-Dependent Relief of Efg1p-Mediated Repression. Genetics 160: 1749-1753 [Abstract] [Full Text]  
  • Singh, P., Ghosh, S., Datta, A. (2001). Attenuation of Virulence and Changes in Morphology in Candida albicans by Disruption of the N-Acetylglucosamine Catabolic Pathway. Infect. Immun. 69: 7898-7903 [Abstract] [Full Text]  
  • Leng, P., Lee, P. R., Wu, H., Brown, A. J. P. (2001). Efg1, a Morphogenetic Regulator in Candida albicans, Is a Sequence-Specific DNA Binding Protein. J. Bacteriol. 183: 4090-4093 [Abstract] [Full Text]  
  • Bockmühl, D. P., Ernst, J. F. (2001). A Potential Phosphorylation Site for an A-Type Kinase in the Efg1 Regulator Protein Contributes to Hyphal Morphogenesis of Candida albicans. Genetics 157: 1523-1530 [Abstract] [Full Text]  
  • Asleson, C. M., Bensen, E. S., Gale, C. A., Melms, A.-S., Kurischko, C., Berman, J. (2001). Candida albicans INT1-Induced Filamentation in Saccharomyces cerevisiae Depends on Sla2p. Mol. Cell. Biol. 21: 1272-1284 [Abstract] [Full Text]  
  • Lengeler, K. B., Davidson, R. C., D'souza, C., Harashima, T., Shen, W.-C., Wang, P., Pan, X., Waugh, M., Heitman, J. (2000). Signal Transduction Cascades Regulating Fungal Development and Virulence. Microbiol. Mol. Biol. Rev. 64: 746-785 [Abstract] [Full Text]  
  • Ernst, J. F. (2000). Transcription factors in Candida albicans - environmental control of morphogenesis. Microbiology 146: 1763-1774 [Full Text]  
  • El Barkani, A., Kurzai, O., Fonzi, W. A., Ramon, A., Porta, A., Frosch, M., Mühlschlegel, F. A. (2000). Dominant Active Alleles of RIM101 (PRR2) Bypass the pH Restriction on Filamentation of Candida albicans. Mol. Cell. Biol. 20: 4635-4647 [Abstract] [Full Text]  
  • Braun, B. R., Johnson, A. D. (2000). TUP1, CPH1 and EFG1 Make Independent Contributions to Filamentation in Candida albicans. Genetics 155: 57-67 [Abstract] [Full Text]  
  • Calera, J. A., Zhao, X.-J., Calderone, R. (2000). Defective Hyphal Development and Avirulence Caused by a Deletion of the SSK1 Response Regulator Gene in Candida albicans. Infect. Immun. 68: 518-525 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»