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Infection and Immunity, August 1999, p. 4183-4190, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Infection of Mice Lacking Interleukin-7 (IL-7) Reveals an Unexpected Role for IL-7 in the Development of the Parasite Schistosoma mansoni

Isabelle Wolowczuk,1,* Sophie Nutten,2 Olivier Roye,1 Myriam Delacre,1 Monique Capron,2 Richard M. Murray,3 François Trottein,2 and Claude Auriault1

Laboratoire d'Immunopathologie Cellulaire des Maladies Infectieuses, UMR 8527, Institut de Biologie,1 and Communication Cellulaire, Mécanismes Effecteurs et Régulateurs, INSERM U167, Institut Pasteur,2 Lille, France, and DNAX Research Institute of Molecular and Cellular Biology, Palo Alto, California3

Received 15 January 1999/Returned for modification 12 March 1999/Accepted 18 May 1999

A single intradermal administration of recombinant interleukin-7 (IL-7) has been shown to aggravate the course of murine schistosomiasis, to favor the development of Th2-associated antibodies specific for the parasite, and to alter migration kinetics and/or migratory route of the parasite within its vertebrate host. Here we show that after infection of IL-7-deficient mice with Schistosoma mansoni, the predominant parasite-specific humoral response follows a Th1 pattern, and the development of the parasite is greatly impaired. In IL-7-deficient mice, increased numbers of larvae reach the lungs and fewer larvae reach the liver, compared to control mice. In the absence of IL-7, female worms show an altered fecundity, leading to decreased numbers of eggs trapped in the tissues and to an amelioration of the pathology of the infected host. The most striking observation is the blockade of parasite growth in an IL-7-defective environment, leading to dwarf male and female worms. The results of this study have important implications for the role of IL-7 in the host-parasite relationship and show how parasites can disable or evade the host immune response.

* Corresponding author. Mailing address: Laboratoire d'Immunopathologie Cellulaire des Maladies Infectieuses, UMR 8527, Institut de Biologie, 1 rue du Pr. A. Calmette, BP 447, F-59021 Lille Cedex, France. Phone: (33) 3 20 87 12 42. Fax: (33) 3 20 87 12 33. E-mail: Isabelle.Wolowczuk{at}pasteur-lille.fr.

Infection and Immunity, August 1999, p. 4183-4190, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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