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Infection and Immunity, August 1999, p. 4285-4289, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Infectivity of Plasmodium berghei Sporozoites Delivered by Intravenous Inoculation versus Mosquito Bite: Implications for Sporozoite Vaccine Trials

Jefferson A. Vaughan,* Libia F. Scheller, Robert A. Wirtz,dagger and Abdu F. Azad

Department of Microbiology & Immunology, University of Maryland School of Medicine, Baltimore, Maryland 21201

Received 19 January 1999/Returned for modification 11 March 1999/Accepted 27 May 1999

Plasmodium berghei sporozoites delivered by mosquito bite were more infectious to outbred CD-1 mice than were sporozoites delivered by intravenous inoculation. The route of challenge also affected vaccine efficacy. In view of these findings and the fact that mosquito bites are the natural mode of sporozoite delivery, infectious mosquito bites should be considered the challenge protocol of choice for sporozoite vaccine efficacy trials.

* Corresponding author. Mailing address: Department of Microbiology & Immunology, University of Maryland at Baltimore, 655 W. Baltimore St., Baltimore, MD 21201. Phone: (410) 706-7066. Fax: (410) 706-2129. E-mail: jvaug001{at}umaryland.edu.

dagger Present address: Entomology Branch, Centers for Disease Control and Prevention, Atlanta, GA.

Infection and Immunity, August 1999, p. 4285-4289, Vol. 67, No. 8
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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