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Infection and Immunity, September 1999, p. 4689-4692, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Genetic Control of Schistosome Infections by the SM1 Locus of the 5q31-q33 Region Is Linked to Differentiation of Type 2 Helper T Lymphocytes

Virmondes Rodrigues Jr.,1,2 Karen Piper,2 Patricia Couissinier-Paris,2 Olivia Bacelar,2 Hélia Dessein,2 and Alain J. Dessein2,*

Laboratorio de Imunologia, Faculdade de Medicina do Triangulo Mineiro, 30, Frei Paulino, 38025-160, Uberaba, MG, Brazil,1 and INSERM U399, Immunology and Genetic of Parasitic Diseases, Faculté de Médecine de Marseille, Université de la Méditerranée, Marseille, France2

Received 29 December 1998/Returned for modification 12 February 1999/Accepted 18 June 1999

Human susceptibility to Schistosoma mansoni infections is controlled by the SM1 locus on chromosome 5 in q31-q33. This genetic region encodes cytokines which regulate the development of helper T lymphocytes. In the present work, a clonal analysis of CD4+ T lymphocytes of homozygous resistant and homozygous susceptible subjects was undertaken to evaluate whether SM1 controls helper T-cell differentiation. Of 121 CD4+ T-cell clones (TCC) from three susceptible (S) and three resistant (R) subjects, 68 proliferated when stimulated by parasite antigens. Parasite-specific TCC derived from susceptible subjects (33 STCC) produced 10- to 1,000-fold less interleukin-4 and -5 than TCC from resistant subjects (25 RTCC). Clones from both patient groups produced, however, the same amount of gamma interferon. Parasite-specific STCC were type 1 helper (Th1) or Th0/1, whereas RTCC were either Th2 or Th0/2. These results, together with the localization of SM1 in 5q31-q33, indicate that the SM1 locus controls the differentiation of Th2 lymphocytes.

* Corresponding author. Mailing address: INSERM U399, Faculté de Médecine de Marseille, 27 Blvd. Jean Moulin, 13385 Marseille, Cedex 5, France. Phone: 04-91-32-44-53. Fax: 04-91-79-60-63. E-mail: Alain.Dessein{at}medecine.univ-mrs.fr.

Infection and Immunity, September 1999, p. 4689-4692, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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