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Infection and Immunity, September 1999, p. 4931-4934, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Virulence of Mycobacterium tuberculosis CDC1551 and H37Rv in Rabbits Evaluated by Lurie's Pulmonary Tubercle Count Method

William R. Bishai,1,2,3 Arthur M. Dannenberg Jr.,1,4,5,6,* Nikki Parrish,6 Rafael Ruiz,1 Ping Chen,2 Bernard C. Zook,7 Walter Johnson,7 James W. Boles,8 and M. Louise M. Pitt8

Departments of Environmental Health Sciences,4 Molecular Microbiology and Immunology,1 International Health,2 and Epidemiology,5 School of Hygiene and Public Health, and Departments of Medicine3 and Pathology,6 School of Medicine, The Johns Hopkins University, Baltimore, Maryland; Departments of Pathology and Animal Research, The George Washington University Medical Center, Washington, D.C.7; and Department of Aerobiology and Product Evaluation, U.S. Army Medical Research Institute of Infectious Diseases, Fort Detrick, Frederick, Maryland8

Received 9 February 1999/Returned for modification 17 February 1999/Accepted 27 May 1999

The virulence of the CDC1551 strain of Mycobacterium tuberculosis was compared to that of H37Rv in a rabbit inhalation model. While rabbits that inhaled the two strains produced equal numbers of grossly visible primary tubercles, CDC1551 tubercles were smaller and contained fewer bacilli than H37Rv tubercles. These findings suggest that a miniepidemic near the Kentucky-Tennessee border caused by CDC1551 was due not to increased virulence but to increased transmissibility.

* Corresponding author. Mailing address: Johns Hopkins School of Hygiene, 615 N. Wolfe St., Baltimore, MD 21205-2179. Phone: (410) 955-3062. Fax: (410) 955-0105. E-mail: artdann{at}jhsph.edu.

Infection and Immunity, September 1999, p. 4931-4934, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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