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Infection and Immunity, September 1999, p. 4935-4938, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.

Age-Associated Differences in Immunoglobulin G1 (IgG1) and IgG2 Subclass Antibodies to Pneumococcal Polysaccharides following Vaccination

Kathleen R. Lottenbach,1,* ChrisAnna M. Mink,2 Stephen J. Barenkamp,1,3 Edwin L. Anderson,1,3 Sharon M. Homan,4 and Douglas C. Powers5

Department of Internal Medicine and Center for Vaccine Development1 and School of Public Health,4 Saint Louis University, and Department of Pediatrics, Saint Louis University School of Medicine and Pediatric Research Institute,3 St. Louis, Missouri; Cedars-Sinai Medical Center, Los Angeles, California2; and Glennan Center for Geriatrics and Gerontology, Eastern Virginia Medical School, Norfolk, Virginia5

Received 10 March 1999/Returned for modification 12 May 1999/Accepted 15 June 1999

Immunoglobulin G (IgG) subclass antibody responses to pneumococcal vaccines were determined for human subjects in four age groups. The ratios of IgG1/IgG2 antibody concentrations declined with advancing age for all five of the serotypes tested. Protein-conjugate vaccines elicited enhanced IgG antibody responses over plain polysaccharide vaccines in infants but not in adult groups.

* Corresponding author. Mailing address: Division of Infectious Diseases and Immunology, Saint Louis University Health Sciences Center, 3635 Vista Ave. at Grand Blvd., FDT-8N, P.O. Box 15250, St. Louis, MO 63110-0250. Phone: (314) 577-8648. Fax: (314) 771-3816. E-mail: lottenkr{at}slu.edu.

Infection and Immunity, September 1999, p. 4935-4938, Vol. 67, No. 9
0019-9567/99/$04.00+0
Copyright © 1999, American Society for Microbiology. All rights reserved.


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