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Infection and Immunity, January 2000, p. 382-386, Vol. 68, No. 1
0019-9567/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Interaction of Enteropathogenic or Enterohemorrhagic Escherichia coli with HeLa Cells Results in Translocation of Cortactin to the Bacterial Adherence Site

Vlademir V. Cantarelli,* Akira Takahashi, Yukihiro Akeda, Kenichi Nagayama, and Takeshi Honda

Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Osaka, Japan

Received 12 July 1999/Returned for modification 27 August 1999/Accepted 5 October 1999

Infection of cultured HeLa epithelial cells with enteropathogenic Escherichia coli (EPEC) or enterohemorrhagic E. coli (EHEC) O157:H7 results in accumulation of cortactin under the adherent bacteria. Tyrosine phosphorylation of cortactin is not induced following HeLa cell infection with EHEC or EPEC, contrary to what has been reported to occur with Shigella flexneri.


* Corresponding author. Mailing address: Department of Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita City, Yamadaoka 3-1, 565-0871 Osaka, Japan. Phone: 81-6-6879-8276. Fax: 81-6-6879-8277. E-mail: vlademir{at}biken.osaka-u.ac.jp.


Infection and Immunity, January 2000, p. 382-386, Vol. 68, No. 1
0019-9567/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.



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