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Infection and Immunity, January 2000, p. 382-386, Vol. 68, No. 1
0019-9567/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Interaction of Enteropathogenic or
Enterohemorrhagic Escherichia coli with HeLa Cells Results
in Translocation of Cortactin to the Bacterial Adherence
Site
Vlademir V.
Cantarelli,*
Akira
Takahashi,
Yukihiro
Akeda,
Kenichi
Nagayama, and
Takeshi
Honda
Department of Bacterial Infections, Research
Institute for Microbial Diseases, Osaka University, Osaka, Japan
Received 12 July 1999/Returned for modification 27 August
1999/Accepted 5 October 1999
Infection of cultured HeLa epithelial cells with enteropathogenic
Escherichia coli (EPEC) or enterohemorrhagic E. coli (EHEC) O157:H7 results in accumulation of cortactin under
the adherent bacteria. Tyrosine phosphorylation of cortactin is not
induced following HeLa cell infection with EHEC or EPEC, contrary to
what has been reported to occur with Shigella flexneri.
*
Corresponding author. Mailing address: Department of
Bacterial Infections, Research Institute for Microbial Diseases, Osaka University, Suita City, Yamadaoka 3-1, 565-0871 Osaka, Japan. Phone:
81-6-6879-8276. Fax: 81-6-6879-8277. E-mail:
vlademir{at}biken.osaka-u.ac.jp.
Infection and Immunity, January 2000, p. 382-386, Vol. 68, No. 1
0019-9567/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
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