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Infection and Immunity, January 2000, p. 391-393, Vol. 68, No. 1
0019-9567/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Plasmodium falciparum Rosette Formation Is Uncommon in Isolates from Pregnant Women

Stephen J. Rogerson,1,2,* James G. Beeson,3 Chisale G. Mhango,4 Fraction K. Dzinjalamala,1 and Malcolm E. Molyneux1,2

Wellcome Trust Research Laboratories1 and Department of Obstetrics and Gynaecology,4 College of Medicine, University of Malawi, Blantyre, Malawi; Liverpool School of Tropical Medicine, University of Liverpool, Liverpool, United Kingdom2; and The Walter and Eliza Hall Institute of Medical Research, Melbourne, Australia3

Received 5 August 1999/Returned for modification 20 September 1999/Accepted 18 October 1999

We examined the formation of Plasmodium falciparum erythrocyte rosettes using parasite isolates from placental or peripheral blood of pregnant Malawian women and from peripheral blood of children. Five of 23 placental isolates, 23 of 38 maternal peripheral isolates, and 136 of 139 child peripheral isolates formed rosettes. Placental isolates formed fewer rosettes than maternal isolates (range, 0 to 7.5% versus 0 to 33.5%; P = 0.002), and both formed fewer rosettes than isolates cultured from children (range, 0 to 56%; P < 0.0001). Rosette formation is common in infections of children but uncommon in pregnancy and rarely detected in placental isolates.

* Corresponding author. Mailing address: Wellcome Trust Research Laboratories, Box 30096, Chichiri, Blantyre 3, Malawi. Phone: 265 676 444. Fax: 265 675 774. E-mail: srogerson{at}malawi.net.

Infection and Immunity, January 2000, p. 391-393, Vol. 68, No. 1
0019-9567/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

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