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Infection and Immunity, January 2000, p. 400-402, Vol. 68, No. 1
0019-9567/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Innate Immunity to Amebic Liver Abscess Is Dependent on Gamma Interferon and Nitric Oxide in a Murine Model of Disease

Karl B. Seydel, Sara J. Smith, and Samuel L. Stanley Jr.*

Departments of Medicine and Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri

Received 8 July 1999/Returned for modification 25 August 1999/Accepted 15 October 1999

Evidence from in vitro studies suggests that gamma interferon (IFN-gamma ) and nitric oxide (NO) are important in host defense against the protozoan parasite Entamoeba histolytica. We used SCID mice with targeted disruption of the IFN-gamma receptor gene and mice with targeted disruption of the gene encoding inducible NO synthase to show that IFN-gamma plays a role in the innate immunity to amebic liver abscess seen in SCID mice while NO is required for control of amebic liver abscess in immunocompetent mice.

* Corresponding author. Mailing address: Department of Medicine, Washington University School of Medicine, Campus Box 8051, 660 S. Euclid Ave., St. Louis, MO 63110. Phone: (314) 362-1070. Fax: (314) 362-3525. E-mail: sstanley{at}imgate.wustl.edu.

Infection and Immunity, January 2000, p. 400-402, Vol. 68, No. 1
0019-9567/0/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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