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Infection and Immunity, October 2000, p. 6038-6040, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Differential Sensitivities of Chlamydia trachomatis Strains to Inhibitory Effects of Gamma Interferon

Richard P. Morrison*

Department of Microbiology, Montana State University, Bozeman, Montana 59717

Received 24 April 2000/Returned for modification 15 June 2000/Accepted 29 June 2000

Gamma interferon (IFN-gamma ) is an important cytokine in host defense against chlamydial infection. An in vitro cell culture system was used to show that IFN-gamma inhibition of chlamydial growth, as determined by diminished recovery of infectious elementary bodies, differed markedly among chlamydial strains. These differences in sensitivity among chlamydial strains to IFN-gamma -mediated inhibition may profoundly influence the clinical outcome of infection.

* Mailing address: Department of Microbiology, Lewis Hall, Room 109, Montana State University, Bozeman, MT 59717. Phone: (406) 994-7959. Fax: (406) 994-7959. E-mail: morrison{at}montana.edu.

Infection and Immunity, October 2000, p. 6038-6040, Vol. 68, No. 10
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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