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Infection and Immunity, November 2000, p. 6493-6495, Vol. 68, No. 11
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

The Nonfunctional Allele TCRBV6S1B Is Strongly Associated with Helicobacter pylori Infection

Erdmute Kunstmann,1,2,* Cornelia Hardt,3 Ercan Elitok,2 Marianne Harder,2 Sebastian Suerbaum,4 Ulrich Peitz,5 Wolff Schmiegel,2 and Jörg T. Epplen1

Department of Molecular Human Genetics, Ruhr-University, 44780 Bochum,1 Department of Internal Medicine, Ruhr-University, 44892 Bochum,2 Institut für Humangenetik, Universitätsklinikum, 45122 Essen,3 Institute of Hygiene and Microbiology, University of Wuerzburg, 97080 Wuerzburg,4 and Medical Department, Otto-von-Guericke-University, 39120 Magdeburg,5 Germany

Received 30 May 2000/Returned for modification 6 July 2000/Accepted 16 August 2000

To determine genetic susceptibility factors for Helicobacter pylori infection, polymorphic T-cell receptor gene elements were investigated in 203 H. pylori-infected individuals and 180 uninfected individuals (controls). H. pylori infection is highly associated with individuals homozygous for the nonfunctional TCRBV6S1B element (odds ratio = 5.9; chi 2 = 13; P = 0.00032; P value corrected for multiple comparisons [Bonferroni correction] = 0.00063).

* Corresponding author. Mailing address: Department of Molecular Human Genetics, Ruhr-University, MA5/142, 44780 Bochum, Germany. Phone: (49) 234 3223823. Fax: (49) 234 3214196. E-mail: Erdmute.M.Kunstmann{at}ruhr-uni-bochum.de.

Infection and Immunity, November 2000, p. 6493-6495, Vol. 68, No. 11
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.




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