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Infection and Immunity, December 2000, p. 7132-7136, Vol. 68, No. 12
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Reactivity of Rheumatic Fever and Scarlet Fever Patients' Sera with Group A Streptococcal M Protein, Cardiac Myosin, and Cardiac Tropomyosin: a Retrospective Study

Kevin F. Jones,1,* Stephen S. Whitehead,2,dagger Madeleine W. Cunningham,3 and Vincent A. Fischetti2

SIGA Research Laboratories, Corvallis, Oregon 973331; Laboratory of Bacterial Pathogenesis and Immunology, Rockefeller University, New York, New York 100212; and Department of Microbiology and Immunology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 731903

Received 1 March 2000/Returned for modification 14 June 2000/Accepted 18 September 2000

Archived sera (collected in 1946) from acute rheumatic fever (ARF) and untreated scarlet fever and/or pharyngitis patients were reacted with streptococcal M protein, cardiac myosin, and cardiac tropomyosin. Except for very low levels to tropomyosin, antibodies to other antigens were not elevated in the sera of ARF patients relative to those of non-ARF patients, even though there was roughly equivalent exposure to group A streptococci. This suggests that antibodies to these molecules may not play a central role in the induction of ARF.

* Corresponding author. Mailing address: SIGA Research Laboratories, 4575 SW Research Way, Suite 230, Corvallis, OR 97333. Phone: (541) 753-2000. Fax: (541) 753-9999. E-mail: kjones{at}sgph.com.

dagger Present address: LID, NIAID, National Institutes of Health, Bethesda, MD 20892-0720.

Infection and Immunity, December 2000, p. 7132-7136, Vol. 68, No. 12
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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