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Infection and Immunity, December 2000, p. 7156-7158, Vol. 68, No. 12
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Cell-Mediated Immune Response during Primary Chlamydia pneumoniae Infection

S. Halme,1,dagger J. Latvala,2 R. Karttunen,3 I. Palatsi,4 P. Saikku,1,3 and H.-M. Surcel1,*

National Public Health Institute,1 Pohja Military Hospital,4 and Department of Microbiology, University of Oulu,3 Oulu, and Lapland Air Command, Rovaniemi,2 Finland

Received 26 May 2000/Returned for modification 12 July 2000/Accepted 13 September 2000

The development of Chlamydia pneumoniae-specific cell-mediated immunity was studied during a primary C. pneumoniae infection. The immune response was detected as positive lymphocyte proliferation and secretion of interferon gamma. C. pneumoniae-induced activation of both CD4+ and CD8+ T cells was detected in the early phase of infection, but activation of only CD4+ T cells was detected in the later stage.

* Corresponding author. Mailing address: National Public Health Institute, Box 310, 90101 Oulu, Finland. Phone: 358-8-5376232. Fax: 358-5376222. E-mail: helja-marja.surcel{at}ktl.fi.

dagger Present address: Labsystems Research Laboratories, Labsystems Oy, 00811 Helsinki, Finland.

Infection and Immunity, December 2000, p. 7156-7158, Vol. 68, No. 12
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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