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Infection and Immunity, December 2000, p. 7195-7197, Vol. 68, No. 12
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Effect of Chlamydia trachomatis Infection on Atherosclerosis in Apolipoprotein E-Deficient Mice

Erwin Blessing,1 Sanae Nagano,1,dagger Lee Ann Campbell,1 Michael E. Rosenfeld,1,2 and Cho-chou Kuo1,*

Department of Pathobiology1 and Interdisciplinary Graduate Program in Nutritional Sciences,2 University of Washington, Seattle, Washington 98195

Received 30 June 2000/Returned for modification 8 September 2000/Accepted 21 September 2000

We have previously demonstrated that Chlamydia pneumoniae accelerates plaque formation in apolipoprotein E-deficient (ApoE-/-) mice following intranasal inoculations. In this study, we evaluated the effect of respiratory tract infection with Chlamydia trachomatis on the progression of atherosclerosis in ApoE-/- mice. The study showed that in contrast to infection with Chlamydia pneumoniae, infection of the lung and aorta with C. trachomatis was mild and transient and did not significantly accelerate plaque development.

* Corresponding author. Mailing address: Department of Pathobiology, Box 357238, University of Washington, Seattle, WA 98195. Phone: (206) 543-8689. Fax: (206) 543-3873. E-mail: cckuo{at}u.washington.edu.

dagger Present address: Department of Obstetrics and Gynecology, Okayama University, Okayama 700-8558, Japan.

Infection and Immunity, December 2000, p. 7195-7197, Vol. 68, No. 12
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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