This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Right arrow Citation Map
Services
Right arrow E-mail this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ASM journals
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Simecka, J. W.
Right arrow Articles by McGhee, J. R.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Simecka, J. W.
Right arrow Articles by McGhee, J. R.

 Previous Article  |  Next Article 

Infection and Immunity, February 2000, p. 672-679, Vol. 68, No. 2
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Mucosally Induced Immunoglobulin E-Associated Inflammation in the Respiratory Tract

Jerry W. Simecka,1,* Raymond J. Jackson,2 Hiroshi Kiyono,2,3 and Jerry R. McGhee2

Department of Molecular Biology and Immunology, University of North Texas Health Science Center in Fort Worth, Fort Worth, Texas 761071; Department of Microbiology and Immunobiology Vaccine Center, University of Alabama at Birmingham, Birmingham, Alabama 352942; and Department of Mucosal Immunology, Research Institute for Microbial Diseases, Osaka University, 3-1 Yamadaoka, Suita, Osaka 565-0871, Japan3

Received 2 July 1999/Returned for modification 21 September 1999/Accepted 17 November 1999

The purpose of the present study was to determine the immunologic responses, particularly immunopathologic reactions, associated with nasal immunization with the mucosal adjuvant, cholera toxin (CT). BALB/c mice were nasally immunized with tetanus toxoid (TT) combined with CT, and the responses of these mice were determined. After nasal immunization, mice produce a serum antibody response, primarily of the immunoglobulin G (IgG) isotype of predominantly IgG1 subclass, against both TT and CT. Along with the antibody responses, we also found that inflammatory reactions, which could be potentially fatal, developed within the lung. Furthermore, IgE responses were also induced after nasal immunization, and these responses were associated with the detection of interleukin 5 in the serum. Thus, nasal immunization with TT plus CT likely results in the activation of Th2 cells, which may contribute to serious immunopathologic reactions in the lung.

* Corresponding author. Mailing address: Department of Molecular Biology and Immunology, University of North Texas Health Science Center, 3500 Camp Bowie Blvd., Fort Worth, TX 76107. Phone: (817) 735-2116. Fax: (817) 735-2118. E-mail: jsimecka{at}hsc.unt.edu.

Infection and Immunity, February 2000, p. 672-679, Vol. 68, No. 2
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Bodhankar, S., Woolard, M. D., Sun, X., Simecka, J. W. (2009). NK Cells Interfere with the Generation of Resistance against Mycoplasma Respiratory Infection following Nasal-Pulmonary Immunization. J. Immunol. 183: 2622-2631 [Abstract] [Full Text]  
  • van Ginkel, F. W., Iwamoto, T., Schultz, B. D., Tomich, J. M. (2008). Immunity to a Self-Derived, Channel-Forming Peptide in the Respiratory Tract. CVI 15: 260-266 [Abstract] [Full Text]  
  • Wikstrom, M. E., Batanero, E., Smith, M., Thomas, J. A., von Garnier, C., Holt, P. G., Stumbles, P. A. (2006). Influence of Mucosal Adjuvants on Antigen Passage and CD4+ T Cell Activation during the Primary Response to Airborne Allergen. J. Immunol. 177: 913-924 [Abstract] [Full Text]  
  • Byrd, W., Cassels, F. J. (2006). The encapsulation of enterotoxigenic Escherichia coli colonization factor CS3 in biodegradable microspheres enhances the murine antibody response following intranasal administration.. Microbiology 152: 779-786 [Abstract] [Full Text]  
  • Fischer, R., McGhee, J. R., Vu, H. L., Atkinson, T. P., Jackson, R. J., Tome, D., Boyaka, P. N. (2005). Oral and Nasal Sensitization Promote Distinct Immune Responses and Lung Reactivity in a Mouse Model of Peanut Allergy. Am. J. Pathol. 167: 1621-1630 [Abstract] [Full Text]  
  • Guthrie, T., Wong, S. Y. C., Liang, B., Hyland, L., Hou, S., Hoiby, E. A., Andersen, S. R. (2004). Local and Systemic Antibody Responses in Mice Immunized Intranasally with Native and Detergent-Extracted Outer Membrane Vesicles from Neisseria meningitidis. Infect. Immun. 72: 2528-2537 [Abstract] [Full Text]  
  • Lavelle, E. C., Jarnicki, A., McNeela, E., Armstrong, M. E., Higgins, S. C., Leavy, O., Mills, K. H. G. (2004). Effects of cholera toxin on innate and adaptive immunity and its application as an immunomodulatory agent. J. Leukoc. Biol. 75: 756-763 [Abstract] [Full Text]  
  • Sehra, S., Pynaert, G., Tournoy, K., Haegeman, A., Matthys, P., Tagawa, Y., Pauwels, R., Grooten, J. (2003). Airway IgG Counteracts Specific and Bystander Allergen-Triggered Pulmonary Inflammation by a Mechanism Dependent on Fc{gamma}R and IFN-{gamma}. J. Immunol. 171: 2080-2089 [Abstract] [Full Text]  
  • Janakova, L., Bakke, H., Haugen, I. L., Berstad, A. K. H., Hoiby, E. A., Aaberge, I. S., Haneberg, B. (2002). Influence of Intravenous Anesthesia on Mucosal and Systemic Antibody Responses to Nasal Vaccines. Infect. Immun. 70: 5479-5484 [Abstract] [Full Text]  
  • Guy, B. (2002). Evaluation of Events Occurring at Mucosal Surfaces: Techniques Used To Collect and Analyze Mucosal Secretions and Cells. CVI 9: 753-762 [Full Text]  
  • Southam, D. S., Dolovich, M., O'Byrne, P. M., Inman, M. D. (2002). Distribution of intranasal instillations in mice: effects of volume, time, body position, and anesthesia. Am. J. Physiol. Lung Cell. Mol. Physiol. 282: L833-L839 [Abstract] [Full Text]  
  • Burkart, V., Kim, Y.-E., Hartmann, B., Ghiea, I., Syldath, U., Kauer, M., Fingberg, W., Hanifi-Moghaddam, P., Muller, S., Kolb, H. (2002). Cholera Toxin B Pretreatment of Macrophages and Monocytes Diminishes Their Proinflammatory Responsiveness to Lipopolysaccharide. J. Immunol. 168: 1730-1737 [Abstract] [Full Text]  
  • Bradney, C. P., Sempowski, G. D., Liao, H.-X., Haynes, B. F., Staats, H. F. (2002). Cytokines as Adjuvants for the Induction of Anti-Human Immunodeficiency Virus Peptide Immunoglobulin G (IgG) and IgA Antibodies in Serum and Mucosal Secretions after Nasal Immunization. J. Virol. 76: 517-524 [Abstract] [Full Text]  
  • Jones, H. P., Hodge, L. M., Fujihashi, K., Kiyono, H., McGhee, J. R., Simecka, J. W. (2001). The Pulmonary Environment Promotes Th2 Cell Responses After Nasal-Pulmonary Immunization with Antigen Alone, but Th1 Responses Are Induced During Instances of Intense Immune Stimulation. J. Immunol. 167: 4518-4526 [Abstract] [Full Text]  
  • Hodge, L. M., Marinaro, M., Jones, H. P., McGhee, J. R., Kiyono, H., Simecka, J. W. (2001). Immunoglobulin A (IgA) Responses and IgE-Associated Inflammation along the Respiratory Tract after Mucosal but Not Systemic Immunization. Infect. Immun. 69: 2328-2338 [Abstract] [Full Text]  


Copyright © 2010 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»