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Infection and Immunity, March 2000, p. 1706-1709, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Effective Preexposure Tuberculosis Vaccines Fail To Protect When They Are Given in an Immunotherapeutic Mode

Joanne Turner,1 Elizabeth R. Rhoades,1 Marc Keen,1 John T. Belisle,1 Anthony A. Frank,2 and Ian M. Orme1,*

Mycobacteria Research Laboratories, Departments of Microbiology1 and Pathology,2 Colorado State University, Fort Collins, Colorado 80523

Received 27 September 1999/Returned for modification 3 November 1999/Accepted 19 November 1999

Two vaccine formulations previously shown to induce protective immunity in mice and prevention of long-term necrosis in guinea pigs were tested as potential immunotherapeutic vaccines in mice earlier infected by aerosol with Mycobacterium tuberculosis. Neither vaccine had any effect on the course of the infection in the lungs, but both reduced the bacterial load in the spleen. Similarly, inoculation with Mycobacterium bovis BCG had no effect whatsoever and, if given more than once, appeared to induce an increasingly severe pyogranulomatous response in the lungs of these mice.

* Corresponding author. Mailing address: Department of Microbiology, Colorado State University, Fort Collins, CO 80523. Phone: (970) 491-5777. Fax: (970) 491-5125. E-mail: iorme{at}lamar.colostate.edu.

Infection and Immunity, March 2000, p. 1706-1709, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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