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Infection and Immunity, March 2000, p. 1724-1726, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Effects of Iron on Extracellular and Intracellular Growth of Penicillium marneffei

D. Taramelli,1,* S. Brambilla,1 G. Sala,1 A. Bruccoleri,1 C. Tognazioli,1 L. Riviera-Uzielli,2 and J. R. Boelaert3

Istituto di Microbiologia, Università di Milano, Milan,1 and Istituto di Microbiologia, Università di Catania, Catania,2 Italy, and Division of Renal and Infectious Diseases, Algemeen Ziekenhuis Sint Jan, 8000 Bruges, Belgium3

Received 4 August 1999/Returned for modification 28 September 1999/Accepted 1 December 1999

Killing of intracellular Penicillium marneffei conidia is demonstrated in gamma interferon-lipopolysaccharide-activated human THP1 and mouse J774 cells. Iron overload significantly reduces the antifungal activity of macrophages. Likewise, exogenous iron enhances and iron chelators inhibit the extracellular growth of P. marneffei. These results suggest that iron availability critically affects immunity to and the pathogenicity of P. marneffei.

* Corresponding author. Mailing address: Istituto di Microbiologia, Università di Milano, Via Pascal 36, 20133 Milano, Italy. Phone: 39 02 26601 221. Fax: 39 02 26601 218. E-mail: Donatella.Taramelli{at}unimi.it.

Infection and Immunity, March 2000, p. 1724-1726, Vol. 68, No. 3
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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