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Infection and Immunity, May 2000, p. 2518-2524, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

rpoS Gene Function Is a Disadvantage for Escherichia coli BJ4 during Competitive Colonization of the Mouse Large Intestine

Karen A. Krogfelt,1,* Marianne Hjulgaard,1 Kristine Sørensen,1 Paul S. Cohen,2 and Michael Givskov3

Department of Gastrointestinal Infections, Statens Serum Institut, DK 2300 Copenhagen,1 and Department of Microbiology, Technical University of Denmark, DK-2800 Lyngby,3 Denmark, and Department of Biochemistry, Microbiology, and Molecular Genetics, University of Rhode Island, Kingston, Rhode Island 028812

Received 8 November 1999/Returned for modification 29 December 1999/Accepted 1 February 2000

The ability of Escherichia coli to survive stress during growth in different environments is, in large part, dependent on rpoS and the genes that comprise the rpoS regulon. E. coli BJ4 and an isogenic BJ4 rpoS mutant were used to examine the influence of the rpoS gene on E. coli colonization of the streptomycin-treated mouse large intestine. Colonization experiments in which the wild-type E. coli BJ4 and its rpoS mutant were fed individually as well as simultaneously to mice suggested that E. coli BJ4 does not face prolonged periods of nutrient starvation in the mouse large intestine and that the rpoS regulon is not expressed during long-term colonization after adaptation of the bacteria to the gut environment.

* Corresponding author. Mailing address: Department of Gastrointestinal Infections, Statens Serum Institut, DK 2300 Copenhagen, Denmark. Phone: 45 3268 3745. Fax: 45 3268 8238. E-mail: KAK{at}ssi.dk.

Infection and Immunity, May 2000, p. 2518-2524, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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