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Infection and Immunity, May 2000, p. 2617-2620, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Cytophilic Immunoglobulin Responses to Plasmodium falciparum Glutamate-Rich Protein Are Correlated with Protection against Clinical Malaria in Dielmo, Senegal

Claude Oeuvray,1 Michael Theisen,2 Christophe Rogier,3 Jean-Francois Trape,4 Søren Jepsen,2 and Pierre Druilhe1,*

Laboratoire de Parasitologie BioMedicale, Institut Pasteur, Paris, France;1 Department of Clinical Biochemistry, Statens Seruminstitut, Copenhagen, Denmark;2 and Institut Pasteur de Dakar3 and Laboratoire de Paludologie, Institut de Recherche pour le Développement,4 Dakar, Sénégal

Received 15 November 1999/Returned for modification 24 January 2000/Accepted 9 February 2000

The goal of this study was to analyze antibody responses to Plasmodium falciparum glutamate-rich protein (GLURP) using clinical data and plasma samples obtained from villagers of Dielmo, Senegal. This molecule was chosen because it is targeted by human antibodies which induce parasite growth inhibition in antibody-dependent cellular inhibition (ADCI) assays. The results showed a strong correlation between protection against malaria attacks and levels of immunoglobulin G2 (IgG2) and IgG3 against GLURP94-489 (R0) and IgG3 against GLURP705-1178 (R2) when corrected for the confounding effect of age-related exposure to malaria. Thus, GLURP may play a role in the induction of protective immunity against P. falciparum malaria.

* Corresponding author. Mailing address: Laboratoire de Parasitologie Bio-Médicale, Institut Pasteur, 28 rue du Dr. Roux, 75015 Paris, France. Phone: (33) 145688578. Fax: (33) 145688640. E-mail: druilhe{at}pasteur.fr.

Infection and Immunity, May 2000, p. 2617-2620, Vol. 68, No. 5
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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