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Infection and Immunity, June 2000, p. 3535-3540, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Bacterial Cell Wall-Induced Arthritis: Chemical Composition and Tissue Distribution of Four Lactobacillus Strains

Egle Simelyte,* Marja Rimpiläinen, Leena Lehtonen, Xiang Zhang, and Paavo Toivanen

Department of Medical Microbiology, Turku Immunology Centre, Turku Graduate School of Biomedical Sciences, Turku University, Turku, Finland

Received 6 December 1999/Returned for modification 18 January 2000/Accepted 23 March 2000

To study what determines the arthritogenicity of bacterial cell walls, cell wall-induced arthritis in the rat was applied, using four strains of Lactobacillus. Three of the strains used proved to induce chronic arthritis in the rat; all were Lactobacillus casei. The cell wall of Lactobacillus fermentum did not induce chronic arthritis. All arthritogenic bacterial cell walls had the same peptidoglycan structure, whereas that of L. fermentum was different. Likewise, all arthritogenic cell walls were resistant to lysozyme degradation, whereas the L. fermentum cell wall was lysozyme sensitive. Muramic acid was observed in the liver, spleen, and lymph nodes in considerably larger amounts after injection of an arthritogenic L. casei cell wall than following injection of a nonarthritogenic L. fermentum cell wall. The L. casei cell wall also persisted in the tissues longer than the L. fermentum cell wall. The present results, taken together with those published previously, underline the possibility that the chemical structure of peptidoglycan is important in determining the arthritogenicity of the bacterial cell wall.

* Corresponding author. Mailing address: Department of Medical Microbiology, Kiinamyllynkatu 13, FIN-20520 Turku, Finland. Phone: 358 2 333 7405. Fax: 358 2 233 0008. E-mail: eglesim{at}utu.fi.

Infection and Immunity, June 2000, p. 3535-3540, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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