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Infection and Immunity, June 2000, p. 3704-3709, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

In Vivo Administration of Mycobacterial Cord Factor (Trehalose 6,6'-Dimycolate) Can Induce Lung and Liver Granulomas and Thymic Atrophy in Rabbits

Naoko Hamasaki,1,2,* Ko-Ichi Isowa,3 Kohachi Kamada,3 Yoshitake Terano,4 Takayuki Matsumoto,2 Tetsuo Arakawa,2 Kazuo Kobayashi,1 and Ikuya Yano1

Departments of Host Defense1 and Gastroenterology,2 Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585, Toneyama Institute for Tuberculosis Research, Toyonaka, Osaka 560-0045,4 and The Center of Japan Biological Chemistry, Kaizu-gunn, Gifu 503-0628,3 Japan

Received 11 October 1999/Returned for modification 25 November 1999/Accepted 15 February 2000

Trehalose 6,6'-dimycolate (TDM) is a cell surface molecule of Mycobacterium tuberculosis. TDM induced a loss of body weight and prominent granulomas in the liver and lungs by the intravenous injection of TDM into rabbits. TDM also induced atrophy of the thymus and spleen due to apoptosis. By contrast, sulfolipid (2,3,6,6'-tetraacyl trehalose 2'-sulfate) induced neither toxicity, nor granuloma formation, nor atrophy of the thymus and spleen. In rabbits the histopathological changes were more dramatic than in mice. The rabbit model may be more sensitive and may provide more information on the beneficial or pathological effects of TDM.

* Corresponding author. Mailing address: Department of Host Defense, Osaka City University Graduate School of Medicine, 1-4-3 Asahi-machi, Abeno-ku, Osaka 545-8585, Japan. Phone: 81-6-6645-3746. Fax: 81-6-6645-3747. E-mail: naoko{at}med.osaka-cu.ac.jp.

Infection and Immunity, June 2000, p. 3704-3709, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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