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Infection and Immunity, June 2000, p. 3744-3747, Vol. 68, No. 6
Institute for Animal Health, Compton,
Newbury, Berkshire, RG20 7NN, United Kingdom
Received 9 December 1999/Returned for modification 10 February
2000/Accepted 28 February 2000
Salmonella enterica serovars Typhimurium and Dublin
lysed primary bovine alveolar macrophages and immortalized J774.2
macrophage-like cells in the absence of either the morphological
changes or DNA fragmentation characteristic of apoptosis. Macrophage
lysis was dependent on a subset of caspases and an intact
sipB gene.
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.
Salmonella enterica Serovars Typhimurium
and Dublin Can Lyse Macrophages by a Mechanism Distinct from
Apoptosis

*
Corresponding author. Mailing address: Institute for
Animal Health, Compton, Newbury, Berkshire, RG20 7NN, United Kingdom. Phone: 44 1635 577230. Fax: 44 1635 577263. E-mail:
timothy.wallis{at}bbsrc.ac.uk.
Present address: Unité de
Mycoplasmologie-Bactériologie, Agence Française de
Sécurité Sanitaire des Aliments, Zoopôle Les Croix
BP53, 22440 Ploufgragan, France.
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