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Infection and Immunity, June 2000, p. 3787-3791, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Characterization of an Anticryptococcal Protein Isolated from Human Serum

Sridevi Sridhar,1 Mala Ahluwalia,1 Elmer Brummer,1,2 and David A. Stevens1,2,*

Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, and California Institute for Medical Research, San Jose,1 and Stanford University School of Medicine, Stanford,2 California

Received 13 December 1999/Returned for modification 27 January 2000/Accepted 19 March 2000

Human serum at low concentrations inhibits the growth of Cryptococcus neoformans in vitro. Fractionation of serum yielded a purified inhibitory protein with a molecular mass of ~81.8 kDa, a pI of ~6.2, and an amino acid sequence that matched that of human transferrin. The inhibitory activity and that of apotransferrin and 5% human serum were reversed by 10 µM freshly prepared FeCl3.

* Corresponding author. Mailing address: Division of Infectious Diseases, Department of Medicine, Santa Clara Valley Medical Center, 751 South Bascom Ave., San Jose, CA 95128-2699. Phone: (408) 885-4313. Fax: (408) 885-4306. E-mail: stevens{at}leland.stanford.edu.

Infection and Immunity, June 2000, p. 3787-3791, Vol. 68, No. 6
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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