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Infection and Immunity, August 2000, p. 4769-4772, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Immunohistochemical Study of Lymphocyte Populations Infiltrating the Gastric Mucosa of Beagle Dogs Experimentally Infected with Helicobacter pylori

Giacomo Rossi,1 Damiano Fortuna,1 Laura Pancotto,2 Giacomo Renzoni,3 Ennio Taccini,1 Paolo Ghiara,2 Rino Rappuoli,2 and Giuseppe Del Giudice2,*

Department of Animal Pathology, Prophylaxis and Food Hygiene, University of Pisa, 50100 Pisa,1 Department of Animal Pathology, University of Camerino, 62032 Camerino,3 and IRIS Chiron SpA Research Center, 53100 Siena,2 Italy

Received 24 November 1999/Returned for modification 24 January 2000/Accepted 3 May 2000

Experimental infection of beagle dogs with Helicobacter pylori induces recruitment to the gastric mucosae of neutrophils at early stages and later of mononuclear cells that organize into lymphoid follicles. These structures become macroscopically evident and consist of peripheral CD4+ T lymphocytes and central CD21+ B lymphocytes. Furthermore, transient expression of interleukin-8 (IL-8) parallels the presence of neutrophils in the gastric mucosae, whereas expression of IL-6 tends to persist chronically.

* Corresponding author. Mailing address: IRIS Chiron SpA Research Center, Via Fiorentina 1, 53100 Siena, Italy. Phone: 39-0577-243261. Fax: 39-0577-243564. E-mail: giuseppe_del_giudice{at}biocine.it.

Infection and Immunity, August 2000, p. 4769-4772, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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