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Infection and Immunity, August 2000, p. 4815-4817, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Polymorphism of Repeated Regions of Pertactin in Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica

Caroline Boursaux-Eude and Nicole Guiso*

Laboratoire des Bordetella, Institut Pasteur, 75724 Paris, France

Received 13 March 2000/Returned for modification 20 April 2000/Accepted 15 May 2000

Pertactin is an outer membrane protein expressed by Bordetella pertussis, Bordetella parapertussis, and Bordetella bronchiseptica that induces protective immunity to Bordetella infections. The immunodominant and immunoprotective epitopes of pertactin include two repeated regions, I and II. Comparison of these two repeated regions showed that B. parapertussis pertactin is invariant, whereas B. pertussis pertactin varies mostly in region I and B. bronchiseptica pertactin varies in both repeated regions I and II, but mostly in region II. These differences may result from specific characteristics of these Bordetella species.

* Corresponding author. Mailing address: Laboratoire des Bordetella, Institut Pasteur, 25 rue du Dr. Roux, 75724 Paris Cedex 15, France. Phone: 33 1 45 68 8334. Fax: 33 1 40 61 35 33. E-mail: nguiso{at}pasteur.fr.

Infection and Immunity, August 2000, p. 4815-4817, Vol. 68, No. 8
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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