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Infection and Immunity, September 2000, p. 5454-5458, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.

Analysis of Genes Expressed at the Infective Larval Stage Validates Utility of Litomosoides sigmodontis as a Murine Model for Filarial Vaccine Development

Judith E. Allen,1,* Jennifer Daub,1 David Guiliano,1 Amanda McDonnell,dagger Michelle Lizotte-Waniewski,2 David W. Taylor,3 and Mark Blaxter1,*

Institute of Cell, Animal, and Population Biology, University of Edinburgh, Edinburgh EH9 3JT,1 and Centre for Tropical Veterinary Medicine, University of Edinburgh, Roslin EH25 9RG,3 United Kingdom, and Clark Science Center, Smith College, Northampton, Massachusetts 010632

Received 18 February 2000/Returned for modification 23 March 2000/Accepted 1 June 2000

We used an expressed sequence tag approach to analyze genes expressed by the infective larvae of the rodent filarial parasite Litomosoides sigmodontis. One hundred fifty two new genes were identified, including several proposed as vaccine candidates in studies with human filarial parasites. Our findings have important implications for the use of L. sigmodontis as a model for filarial infection.

* Corresponding author. Mailing address: Institute of Cell, Animal and Population Biology, University of Edinburgh, Edinburgh EH9 3JT, United Kingdom. Phone: 44 131 650 7014. Fax: 44 131 650 5450. E-mail for Judith E. Allen: j.allen{at}ed.ac.uk. E-mail for Mark Blaxter: m.blaxter{at}ed.ac.uk.

dagger Present address: Institute for Animal Health, Ogston Building, Edinburgh, EH9 3JF, United Kingdom.

Infection and Immunity, September 2000, p. 5454-5458, Vol. 68, No. 9
0019-9567/00/$04.00+0
Copyright © 2000, American Society for Microbiology. All rights reserved.


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