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Infection and Immunity, January 2001, p. 221-227, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.221-227.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Haemophilus influenzae Porin Contributes to Signaling of the Inflammatory Cascade in Rat Brain

Massimiliano Galdiero,1 Michele D'Amico,2 Fernanda Gorga,3 Clara Di Filippo,2 Marina D'Isanto,3 Mariateresa Vitiello,3,* Anna Longanella,3 and Annalisa Tortora3

Dipartimento di Patologia e Sanità Animale, Facoltà di Veterinaria, Università degli Studi di Napoli Federico I, 80137 Naples,1 and Istituto di Farmacologia e Tossicologia2 and Istituto di Microbiologia,3 Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, 80138 Naples, Italy

Received 17 July 2000/Returned for modification 1 September 2000/Accepted 6 October 2000

In the present study we observed that the Haemophilus influenzae type b (Hib) porin, among the different surface bacterial components, is involved in the pathophysiology of bacterial meningitis. This study demonstrates that inoculation of Hib porin into the fourth cerebral ventricle causes the simultaneous expression of interleukin-1alpha (IL-1alpha ), tumor necrosis factor alpha (TNF-alpha ), and macrophage inflammatory protein 2 (MIP-2) at 6 h after inoculation. At 24 h, the expression of MIP-2 decreases while the expression of IL-1alpha and TNF-alpha increases. The mRNA expression of IL-1alpha , TNF-alpha , and MIP-2 is correlated with injury to the blood-brain barrier as demonstrated by the appearance of serum proteins and leukocytes in cerebrospinal fluid and by the increase in brain water content.

* Corresponding author. Mailing address: Istituto di Microbiologia, Facoltà di Medicina e Chirurgia, Seconda Università degli Studi di Napoli, Larghetto S. Aniello a Caponapoli no. 2, 80138 Naples, Italy. Phone: 39-081-5665662. Fax: 39-081-5665663. E-mail: francesco.galdiero{at}unina2.it.

Infection and Immunity, January 2001, p. 221-227, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.221-227.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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