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Infection and Immunity, January 2001, p. 589-592, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.589-592.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Severe Schistosomiasis in the Absence of Interleukin-4 (IL-4) Is IL-12 Independent

Elisabeth A. Patton,1 Laura Rosa Brunet,1,dagger Anne C. La Flamme,1 João Pedras-Vasconcelos,1,Dagger Manfred Kopf,2 and Edward J. Pearce1,*

Department of Microbiology and Immunology, College of Veterinary Medicine, Cornell University, Ithaca, New York,1 and Basel Institute for Immunology, Basel, Switzerland2

Received 7 August 2000/Returned for modification 8 September 2000/Accepted 29 September 2000

An interleukin-4 (IL-4)-dependent Th2 response allows wild-type mice to survive infection with the parasite Schistosoma mansoni. In the absence of IL-4, infected mice mount a Th1-like proinflammatory response, develop severe disease, and succumb. Neither the Th1 response nor morbidity is IL-12 dependent in this system.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, C5-165 VMC, College of Veterinary Medicine, Cornell University, Ithaca, NY 14853. Phone: (607) 253-3389. Fax: (607) 253-3384. E-mail: ejp2{at}cornell.edu.

dagger Present address: Division of Microbiology and Parasitology, Department of Pathology, University of Cambridge, Cambridge, United Kingdom.

Dagger Present address: Institute for Biological Sciences, National Research Council, Ottawa, Ontario, Canada.

Infection and Immunity, January 2001, p. 589-592, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.589-592.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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