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Infection and Immunity, January 2001, p. 617-621, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.617-621.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

T-Cell Responses to Immunodominant LACK Antigen Do Not Play a Critical Role in Determining Susceptibility of BALB/c Mice to Leishmania mexicana

Fabiola Aguilar Torrentera,1,2,dagger Nicolas Glaichenhaus,3 Jon D. Laman,4 and Yves Carlier1,*

Laboratoire de Parasitologie, Université Libre de Bruxelles (ULB), Brussels, Belgium1; Institut de Pharmacologie Moléculaire et Cellulaire, CNRS, Valbonne, France3; Department of Immunology, Erasmus University Rotterdam (EUR), Rotterdam, The Netherlands4; and Departamento de Inmunologia, Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Mexico City, Mexico2

Received 17 July 2000/Returned for modification 8 September 2000/Accepted 23 October 2000

Although BALB/c mice develop lesions when infected with Leishmania mexicana, the mechanisms which are responsible for susceptibility to this parasite have not been elucidated. In contrast, susceptibility of BALB/c mice to Leishmania major has been shown to depend on the early production of interleukin-4 (IL-4) by T cells which react to the parasitic LACK antigen. Here, we demonstrate that the lesions induced by L. mexicana are delayed compared to those induced by L. major but rapidly develop at later time points. Interestingly, while LACK-tolerant BALB/c-derived IE-LACK transgenic mice were resistant to L. major, they were susceptible to L. mexicana and developed lesions similar to those observed in wild-type BALB/c mice. The latter result was observed despite the fact that (i) LACK was expressed by L. mexicana, (ii) splenocytes from BALB/c mice were able to stimulate LACK-specific T-cell hybridoma cells when incubated with live L. mexicana promastigotes, and (iii) LACK-specific T cells contributed to IL-4 production in L. mexicana-infected BALB/c mice. Thus, in contrast to what was observed for L. major-infected mice, LACK-specific T cells do not play a critical role in determining susceptibility to L. mexicana. Although BALB/c mice are susceptible to both L. major and L. mexicana, the mechanisms which are responsible for susceptibility to these parasites are likely to be different.

* Corresponding author. Mailing address: Laboratoire de Parasitologie, Faculté de Médecine, ULB, CP 616, Route de Lennik 808, B-1070 Brussels, Belgium. Phone: 32 2 555 62 55. Fax: 32 2 555 61 28. E-mail: ycarlier{at}ulb.ac.be.

dagger Present address: Escuela Nacional de Ciencias Biologicas, Instituto Politecnico Nacional, Mexico City, Mexico.

Infection and Immunity, January 2001, p. 617-621, Vol. 69, No. 1
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.1.617-621.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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