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Infection and Immunity, October 2001, p. 6545-6548, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6545-6548.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Toxicity of Shiga Toxin 1 in the Central Nervous System of Rabbits

Jun Fujii,1,* Yoshimasa Kinoshita,2 Takashi Yutsudo,3 Hatsumi Taniguchi,1 Tom Obrig,4 and Shin-Ichi Yoshida5

Departments of Microbiology1 and Neurosurgery,2 School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Shionogi and Co. Ltd., Osaka 561,3 and Department of Bacteriology, Graduate School of Medical Sciences, Kyushu University, Fukuoka 812-8582,5 Japan, and Division of Nephrology, University of Virginia, Charlottesville, Virginia 229084

Received 25 April 2001/Returned for modification 5 June 2001/Accepted 9 July 2001

The action of Shiga toxin (Stx) on the central nervous system was examined in rabbits. Intravenous Stx1 was 44 times more lethal than Stx2 and acted more rapidly than Stx2. However, Stx1 accumulated more slowly in the cerebrospinal fluid than did Stx2. Magnetic resonance imaging demonstrated a predominance of Stx1-dependent lesions in the spinal cord. Pretreatment of the animals with anti-Stx1 antiserum intravenously completely protected against both development of brain lesions and mortality.

* Corresponding author. Mailing address: Department of Microbiology, School of Medicine, University of Occupational and Environmental Health, Kitakyushu 807-8555, Japan. Phone: 81-93-691-7242. Fax: 81-93-602-4799. E-mail: jfujii{at}med.uoeh-u.ac.jp.

Infection and Immunity, October 2001, p. 6545-6548, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6545-6548.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • Sauter, K. A. D., Melton-Celsa, A. R., Larkin, K., Troxell, M. L., O'Brien, A. D., Magun, B. E. (2008). Mouse Model of Hemolytic-Uremic Syndrome Caused by Endotoxin-Free Shiga Toxin 2 (Stx2) and Protection from Lethal Outcome by Anti-Stx2 Antibody. Infect. Immun. 76: 4469-4478 [Abstract] [Full Text]  


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