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Infection and Immunity, October 2001, p. 6549-6553, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6549-6553.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Environmental Signals Controlling Production of Hemagglutinin/Protease in Vibrio cholerae

Jorge A. Benitez,1,* Anisia J. Silva,2 and Richard A. Finkelstein3

California State University College of Science and Mathematics, Fresno, California 93740-80341; University of California--- Davis School of Veterinary Medicine and Veterinary Diagnostic Laboratory, Tulare, California 932742; and Department of Molecular Microbiology and Immunology, University of Missouri School of Medicine, Columbia, Missouri 652123

Received 17 May 2001/Returned for modification 4 June 2001/Accepted 2 July 2001

Vibrio cholerae hemagglutinin/protease (Hap) was induced upon nutrient limitation and strongly repressed by glucose. Hap was not produced in a mutant defective in the cyclic AMP (cAMP) receptor protein, suggesting that intracellular cAMP levels mediate Hap expression. No difference was found in Hap production between an rpoS deletion mutant and its isogenic wild-type precursor, indicating that the alternate sigma s factor is not essential for Hap expression. Based on these and previous results, we discuss the role of Hap in the pathogenesis of cholera.

* Corresponding author. Mailing address: California State University College of Science and Mathematics, 2555 East San Ramon Ave. M/S SB73, Fresno, CA 93740-8034. Phone: (559) 278-5620. Fax: (559) 278-3963. E-mail: jbenitez{at}csufresno.edu.

Infection and Immunity, October 2001, p. 6549-6553, Vol. 69, No. 10
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.10.6549-6553.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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