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Infection and Immunity, November 2001, p. 7100-7105, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7100-7105.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Relative Importance of NF-kappa B p50 in Mycobacterial Infection

Hiroyuki Yamada, Satoru Mizuno, Mohammad Reza-Gholizadeh, and Isamu Sugawara*

Department of Molecular Pathology, The Research Institute of Tuberculosis, Tokyo 204-0022, Japan

Received 6 June 2001/Returned for modification 12 July 2001/Accepted 27 July 2001

To understand the role of NF-kappa B in the development of murine tuberculosis in vivo, NF-kappa B p50 knockout mice were infected with Mycobacterium tuberculosis by placing them in the exposure chamber of an airborne-infection apparatus. These mice developed multifocal necrotic pulmonary lesions or lobar pneumonia. Compared with the levels in wild-type mice, pulmonary inducible nitric oxide synthase, interleukin-2 (IL-2), gamma interferon, and tumor necrosis factor alpha mRNA levels were significantly low but expression of IL-10 and transforming growth factor beta  mRNAs were within the normal ranges. The pulmonary IL-6 mRNA expression level was higher. Therefore, NF-kappa B and its interaction with host cells play an important role in the pathogenesis of tuberculosis.

* Corresponding author. Mailing address: Department of Molecular Pathology, The Research Institute of Tuberculosis, 3-1-24 Matsuyama, Kiyose, Tokyo 204-0022, Japan. Phone: 81 424 93 5075. Fax: 81 424 92 4600. E-mail: sugawara{at}jata.or.jp.

Infection and Immunity, November 2001, p. 7100-7105, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7100-7105.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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