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Infection and Immunity, November 2001, p. 7159-7161, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7159-7161.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Histopathological Studies on Virulence of Dipeptidyl Aminopeptidase IV (DPPIV) of Porphyromonas gingivalis in a Mouse Abscess Model: Use of a DPPIV-Deficient Mutant

Hisao Yagishita,1 Yumi Kumagai,2,* Kiyoshi Konishi,2 Yukihiro Takahashi,2 Takaaki Aoba,1 and Masanosuke Yoshikawa2

Department of Pathology1 and Department of Microbiology,2 Nippon Dental University, Fujimi 1-9-20, Chiyoda-ku, Tokyo 102-8159, Japan

Received 31 January 2001/Returned for modification 24 April 2001/Accepted 23 July 2001

To elucidate the role of dipeptidyl aminopeptidase IV (DPPIV) in the virulence of Porphyromonas gingivalis, mice were infected with either a wild-type strain or a DPPIV-deficient mutant using an abscess model. Histopathological analysis of the resulting lesions indicated that DPPIV participates in virulence through the destruction of connective tissue and the less effective mobilization of inflammatory cells.

* Corresponding author. Mailing address: Department of Microbiology, Nippon Dental University, Fujimi 1-9-20, Chiyoda-ku, Tokyo 102-8159, Japan. Phone: 81-3-3261-8763. Fax: 81-3-3264-8399. E-mail: yumi-mic{at}tokyo.ndu.ac.jp.

Infection and Immunity, November 2001, p. 7159-7161, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7159-7161.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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