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Infection and Immunity, November 2001, p. 7165-7168, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7165-7168.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

High-Level Expression of NRAMP1 in Peripheral Blood Cells and Tuberculous Granulomas from Mycobacterium bovis-Infected Bovines

Ciro Estrada-Chávez,1,2 Ana L. Pereira-Suárez,2 Marco A. Meraz,2 Camila Arriaga,1 Alejandro García-Carrancá,3 Cristina Sánchez-Rodriguez,4 and Raúl Mancilla4,*

Centro Nacional de Investigación Disciplinaria en Microbiología, INIFAP, Palo Alto, Mexico City, 05110,1 Departamento de Biomedicina Molecular, Centro de Investigaciones y de Estudios Avanzados, IPN, San Pedro Zacatenco, Mexico City, 07360,2 and Departamento de Biología Molecular3 and Departamento de Immunología, Instituto de Investigaciones Biomédicas,4 UNAM, Mexico City, 04510, Mexico

Received 9 May 2001/Returned for modification 7 July 2001/Accepted 6 August 2001

By Western blotting, we demonstrate high-level expression of NRAMP1 proteins in peripheral blood cells and granulomas of Mycobacterium bovis-infected bovines. Immunohistochemistry of granulomatous lesions showed heavily labeled epithelioid macrophages and Langhans cells. These data suggest that M. bovis infection enhances NRAMP1 expression and that active tuberculosis can occur despite this response.

* Corresponding author. Mailing address: Departamento de Inmunología, Instituto de Investigaciones Biomédicas, UNAM, Apartado Postal 70-228, 04510 Mexico City, Mexico. Phone: (525)6223868. Fax: (525)6223369. E-mail: mancilla{at}servidor.unam.mx.

Infection and Immunity, November 2001, p. 7165-7168, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7165-7168.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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