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Infection and Immunity, November 2001, p. 7182-7186, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7182-7186.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mycobacterium ulcerans Cytotoxicity in an Adipose Cell Model

Karen M. Dobos,1,* Pamela L. Small,2 Manon Deslauriers,3 Fredrick D. Quinn,3 and C. Harold King1

Department of Medicine, Emory University School of Medicine, Emory University, Atlanta, Georgia 303031; Department of Microbiology, University of Tennessee, Knoxville, Tennessee 379962; and Division of AIDS, STD, and TB Laboratory Research, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 303333

Received 31 May 2001/Returned for modification 10 July 2001/Accepted 10 August 2001

An adipose cell (SW872) model was developed to observe cellular necrosis and apoptosis upon Mycobacterium ulcerans infection and treatment with mycobacterial exudate. Apoptosis was likely due to secreted proteins, while necrosis was likely due to mycolactone. Our data suggest that additional factors in M. ulcerans may be involved in Buruli ulcer pathogenesis.

* Corresponding author. Present address: Mayo Clinic Scottsdale, S. C. Johnson Research Building, 13400 E. Shea Blvd., Scottsdale, AZ 85259. Phone: (480) 301-3215. Fax: (480) 301-7017. E-mail: dobos.karen{at}mayo.edu.

Infection and Immunity, November 2001, p. 7182-7186, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7182-7186.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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