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Infection and Immunity, November 2001, p. 7190-7193, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7190-7193.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Identity of Activation Molecule 3 on Superantigen-Stimulated Bovine Cells Is CD26

Sang-Un Lee,1 Witold Ferens,1 William C. Davis,2 Mary Jo Hamilton,2 Yong-Ho Park,3 Lawrence K. Fox,4 Jan Naessens,5 and Gregory A. Bohach1,*

Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, Idaho 838441; Department of Veterinary Microbiology and Pathology2 and Department of Veterinary Clinical Medicine and Surgery,4 Washington State University, Pullman, Washington 99163; Department of Microbiology, College of Veterinary Medicine and School of Agricultural Biotechnology, Seoul National University, Seoul, Korea3; and International Livestock Research Institute, Nairobi, Kenya5

Received 19 June 2001/Returned for modification 1 August 2001/Accepted 20 August 2001

Most CD8+ T cells in cultures of bovine mononuclear cells stimulated with staphylococcal enterotoxin C1 develop an unusual phenotype characterized by expression of activation molecule 3 (ACT3). This superantigen-dependent phenotype may be relevant to immunopathogenesis mediated by certain microbial toxins. The size and N-terminal sequence of immunoprecipitated ACT3 indicate that ACT3 is the bovine orthologue of CD26.

* Corresponding author. Mailing address: Department of Microbiology, Molecular Biology, and Biochemistry, University of Idaho, Moscow, ID 83844-3052. Phone: (208) 885-6666. Fax: (208) 885-6518. E-mail: gbohach{at}uidaho.edu.

Infection and Immunity, November 2001, p. 7190-7193, Vol. 69, No. 11
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.11.7190-7193.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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