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Infection and Immunity, December 2001, p. 7419-7424, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7419-7424.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Mouse Strain-Dependent Chemokine Regulation of the Genital Tract T Helper Cell Type 1 Immune Response

Toni Darville,1,2,* Charles W. Andrews Jr.,3 James D. Sikes,1,2 Patrick L. Fraley,1,2 Leah Braswell,1,2 and Roger G. Rank2

Department of Pediatric Infectious Diseases, Arkansas Children's Hospital,1 and Department of Microbiology and Immunology,2 University of Arkansas for Medical Sciences, Little Rock, Arkansas, and Department of Pathology, Sacred Heart Medical Center, Spokane, Washington3

Received 10 July 2001/Returned for modification 10 August 2001/Accepted 18 September 2001

Vaginal infection with the mouse pneumonitis agent of Chlamydia trachomatis (MoPn) produces shorter courses of infection in C57BL/6 and BALB/c mice than in C3H/HeN mice, while C57BL/6 mice are more resistant to oviduct pathology. A robust Th1 response is extremely important in host defense against chlamydia. In this study we examined gamma interferon (IFN-gamma ), interleukin 10 (IL-10), and the T-cell-regulatory chemokines macrophage inflammatory protein-1alpha (MIP-1alpha ) and monocyte chemoattractant protein-1 (MCP-1) to determine if differences in these responses were associated with the differential courses of infection seen in these three strains of mice. Increased and prolonged IFN-gamma responses and lower IL-10 responses were observed in the C57BL/6 strain compared to BALB/c and C3H. Examination of genital tract chemokines revealed a marked predominance of MIP-1alpha over MCP-1 only in the C57 strain. Thus, a pattern of high MIP-1alpha and low MCP-1 levels during the first week of infection is associated with an increased Th1 response and a shorter, more benign chlamydial infection. Inhibition of the MCP-1 response in C3H mice increased their later T-cell production of IFN-gamma but decreased their early IFN-gamma response and had no effect on the course or outcome of infection. Inhibition of MCP-1 is not beneficial in chlamydial infection because of its pleiotropic effects.

* Corresponding author. Mailing address: Department of Pediatrics and Microbiology and Immunology, Slot 511, B506C, University of Arkansas for Medical Sciences, Little Rock, AR 72202. Phone: (501) 686-7430. Fax: (501) 320-3551. E-mail: darvilletonil{at}uams.edu.

Infection and Immunity, December 2001, p. 7419-7424, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7419-7424.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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