This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via HighWire
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Spencer, L.
Right arrow Articles by Rajan, T. V.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Spencer, L.
Right arrow Articles by Rajan, T. V.

 Previous Article  |  Next Article 

Infection and Immunity, December 2001, p. 7743-7752, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7743-7752.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Interleukin-4 Receptor-Stat6 Signaling in Murine Infections with a Tissue-Dwelling Nematode Parasite

L. Spencer,1 L. Shultz,2 and T. V. Rajan1,*

Department of Pathology, University of Connecticut Health Center, Farmington, Connecticut,1 and Jackson Laboratories, Bar Harbor, Maine2

Received 2 May 2001/Returned for modification 2 July 2001/Accepted 4 September 2001

Interleukin-4 (IL-4) has been shown to be crucial in parasite expulsion in several gastrointestinal nematode infection models. Data from both epidemiological studies with humans and experimental infections in animals imply a critical role for the type II helper response, dominated by IL-4, in host protection. Here we utilized inbred mice on two distinct backgrounds to document the involvement of IL-4 in the clearance of a primary infection of Brugia from the murine host. Our data from infections of IL-4 receptor-/- and Stat6-/- mice further indicate that IL-4 exerts its effects by activating the Stat6 molecule in host target cells, a finding which links clearance requirements of a gastrointestinal tract-dwelling nematode with those of a tissue-dwelling nematode. Additionally, we show that the requirements for IL-4 receptor binding and Stat6 activation extend to accelerated clearance of a secondary infection as well. The data shown here, including analysis of cell populations at the site of infection and infection of immunoglobulin E (IgE)-/- mice, lead us to suggest that deficiencies in eosinophil recruitment and isotype switching to IgE production may be at least partially responsible for slower parasite clearance in the absence of IL-4.

* Corresponding author. Mailing address: Department of Pathology, University of Connecticut Health Center, 263 Farmington Ave., Farmington, CT 06030-3105. Phone: (860) 679-3221. Fax: (860) 679-2936. E-mail: rajan{at}neuron.uchc.edu.

Infection and Immunity, December 2001, p. 7743-7752, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7743-7752.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • McSorley, H. J., Harcus, Y. M., Murray, J., Taylor, M. D., Maizels, R. M. (2008). Expansion of Foxp3+ Regulatory T Cells in Mice Infected with the Filarial Parasite Brugia malayi. J. Immunol. 181: 6456-6466 [Abstract] [Full Text]  
  • de Bree, G. J., van Leeuwen, E. M.M., Out, T. A., Jansen, H. M., Jonkers, R. E., van Lier, R. A.W. (2005). Selective accumulation of differentiated CD8+ T cells specific for respiratory viruses in the human lung. JEM 202: 1433-1442 [Abstract] [Full Text]  
  • Rajan, B., Ramalingam, T., Rajan, T. V. (2005). Critical Role for IgM in Host Protection in Experimental Filarial Infection. J. Immunol. 175: 1827-1833 [Abstract] [Full Text]  
  • Abraham, D., Leon, O., Schnyder-Candrian, S., Wang, C. C., Galioto, A. M., Kerepesi, L. A., Lee, J. J., Lustigman, S. (2004). Immunoglobulin E and Eosinophil-Dependent Protective Immunity to Larval Onchocerca volvulus in Mice Immunized with Irradiated Larvae. Infect. Immun. 72: 810-817 [Abstract] [Full Text]  
  • Spencer, L., Shultz, L., Rajan, T. V. (2003). T Cells Are Required for Host Protection against Brugia malayi but Need Not Produce or Respond to Interleukin-4. Infect. Immun. 71: 3097-3106 [Abstract] [Full Text]  
  • Spencer, L. A., Porte, P., Zetoff, C., Rajan, T. V. (2003). Mice Genetically Deficient in Immunoglobulin E Are More Permissive Hosts than Wild-Type Mice to a Primary, but Not Secondary, Infection with the Filarial Nematode Brugia malayi. Infect. Immun. 71: 2462-2467 [Abstract] [Full Text]  
  • Paciorkowski, N., Shultz, L. D., Rajan, T. V. (2003). Primed Peritoneal B Lymphocytes Are Sufficient To Transfer Protection against Brugia pahangi Infection in Mice. Infect. Immun. 71: 1370-1378 [Abstract] [Full Text]  


Copyright © 2009 by the American Society for Microbiology.   For an alternate route to Journals.ASM.org, visit: http://intl-journals.asm.org | More Info»