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Infection and Immunity, December 2001, p. 7922-7926, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7922-7926.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Limited Mycobacterial Infection of the Liver as a Consequence of Its Microanatomical Structure Causing Restriction of Mycobacterial Growth to Professional Phagocytes

Peter Seiler,1 Reto A. Schwendener,2 Silke Bandermann,1 Volker Brinkmann,1 Leander Grode,1 Stefan H. E. Kaufmann,1,* and Peter Aichele1

Max Planck Institute for Infection Biology, D-10117 Berlin, Germany,1 and Paul Scherrer Institute, CH-5232 Villigen, Switzerland2

Received 1 June 2001/Returned for modification 7 August 2001/Accepted 31 August 2001

Among sites of extrapulmonary growth of Mycobacterium tuberculosis, the liver is the least infected. Our data suggest that this is due to the complete restriction of mycobacterial growth to liver macrophages. Unlike in organs more persistently seeded by M. tuberculosis, in the liver the bacteria do not infect cell types other than professional phagocytes.

* Corresponding author. Mailing address: Max Planck Institute for Infection Biology, Schumannstr. 21/22, D-10117 Berlin, Germany. Phone: 493028460500. Fax: 493028460501. E-mail: kaufmann{at}mpiib-berlin.mpg.de.

Infection and Immunity, December 2001, p. 7922-7926, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7922-7926.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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