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Infection and Immunity, December 2001, p. 7955-7958, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7955-7958.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Innate Resistance to Babesia Infection Is Influenced by Genetic Background and Gender

Irma Aguilar-Delfin,1 Mary J. Homer,2 Peter J. Wettstein,1 and David H. Persing2,3,*

Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905,1 and Corixa Corporation2 and The Infectious Disease Research Institute,3 Seattle, Washington 981043

Received 13 February 2001/Returned for modification 6 April 2001/Accepted 21 August 2001

Infection of severe combined immunodeficient mice with Babesia sp. strain WA1 was studied to assess the contributions of innate and adaptive immunity in resistance to acute babesiosis. The scid mutation showed little effect in genetically susceptible C3H mice and did not decrease the inherent resistance of C57BL/6 mice to the infection, suggesting that innate immunity plays a central role in determining the course of Babesia infection in these strains. In contrast, the scid mutation dramatically impaired resistance in moderately susceptible BALB/c mice, suggesting that acquired immunity may play an important secondary role. In comparison to their female counterparts, male mice of different genetic backgrounds showed increased resistance to the infection, indicating that the gender of the host may influence protection against babesiosis.

* Corresponding author. Mailing address: Corixa Corporation, Suite 200, 1124 Columbia St., Seattle, WA 98104. Phone: (206) 754-5879. Fax: (206) 754-5917. E-mail: persing{at}corixa.com.

Infection and Immunity, December 2001, p. 7955-7958, Vol. 69, No. 12
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.12.7955-7958.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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