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Infection and Immunity, March 2001, p. 1922-1923, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1922-1923.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Variant-Specific Surface Protein Switching in Giardia lamblia

T. E. Nash,* H. T. Luján,dagger M. R. Mowatt,Dagger and J. T. Conrad

Laboratory of Parasitic Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland

Received 7 September 2000/Returned for modification 23 October 2000/Accepted 25 November 2000

Surface antigen switching in Giardia lamblia was analyzed using monoclonal antibodies specific for two variant-specific surface proteins (VSPs). Two VSPs were detected on the surface of single trophozoites. Dual expression persisted for 13 h but disappeared at 36 h, as in other parasites that undergo surface antigenic variation.

* Corresponding author. Mailing address: National Institutes of Health, 9000 Rockville Pike, Bldg. 4, Rm. B1-06, Bethesda, MD 20892. Phone: (301) 496-6920. Fax: (301) 402-2689. E-mail: tnash{at}niaid.nih.gov.

dagger Present address: Cátedra de Química Biológica, Facultad de Ciencias Médicas, Universidad Nacional de Córdoba, Córdoba, Argentina.

Dagger Present address: Office of Technology Development, National Institutes of Health, Bethesda, MD 20892.

Infection and Immunity, March 2001, p. 1922-1923, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1922-1923.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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