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Infection and Immunity, March 2001, p. 1971-1973, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1971-1973.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Circumvention of Herd Immunity during an Outbreak of Meningococcal Disease Could Be Correlated to Escape Mutation in the porA Gene of Neisseria meningitidis

Muhamed-Kheir Taha,1,* Edouard Bichier,2 Anne Perrocheau,3 and Jean-Michel Alonso1

Unité des Neisseria and Centre National de Référence des Méningocoques, Institut Pasteur, 75724 Paris Cedex 15,1 Laboratoire du Centre Hospitalier de Saumur, 49403 Saumur Cedex,2 and Institut de Veille Sanitaire, 94415 Saint Maurice Cedex,3 France

Received 23 August 2000/Returned for modification 12 December 2000/Accepted 19 December 2000

Meningococcal strains isolated during an outbreak were shown to belong to the ET-5 complex and to harbor a mutation in the VR2 region of the porA gene. They were less susceptible to the bactericidal effect of normal human serum than was the ET-5 wild-type strain. These results are of concern, as PorA is a potential target in vaccine design.

* Corresponding author. Mailing address: Unité des Neisseria and Centre National de Référence des Méningococques, Institut Pasteur, 28 rue du Dr Roux, 75724 Paris cedex 15, France. Phone: 33(0)1 45 68 84 38. Fax: 33(0)1 45 68 83 38. E-mail: mktaha{at}pasteur.fr.

Infection and Immunity, March 2001, p. 1971-1973, Vol. 69, No. 3
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.3.1971-1973.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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