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Infection and Immunity, April 2001, p. 2462-2469, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2462-2469.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Guillain-Barré Syndrome- and Miller Fisher Syndrome-Associated Campylobacter jejuni Lipopolysaccharides Induce Anti-GM1 and Anti-GQ1b Antibodies in Rabbits

C. W. Ang,1,2,3 M. A. De Klerk,1,2,3,* H. P. Endtz,3,4 B. C. Jacobs,1,2,3 J. D. Laman,2,3 F. G. A. van der Meché,1,3 and P. A. van Doorn1,3

Departments of Neurology,1 Immunology,2 and Medical Microbiology & Infectious Diseases,4 Erasmus University, and Dijkzigt University Hospital,3 Rotterdam, The Netherlands

Received 23 June 2000/Returned for modification 7 September 2000/Accepted 22 January 2001

Campylobacter jejuni infections are thought to induce antiganglioside antibodies in patients with Guillain-Barré syndrome (GBS) and Miller Fisher syndrome (MFS) by molecular mimicry between C. jejuni lipopolysaccharides (LPS) and gangliosides. We used purified LPS fractions from five Campylobacter strains to induce antiganglioside responses in rabbits. The animals that received injections with LPS from GBS-associated strains developed anti-GM1 and anti-GA1 antibodies. Animals injected with LPS from one MFS-related C. jejuni strain produced anti-GQ1b antibodies. Rabbits that were injected with Penner O:3 LPS had a strong anti-LPS response, but no antiganglioside reactivity was observed. The antiganglioside specificity in the rabbits reflected the specificity in the patients from whom the strains were isolated. In conclusion, our results indicate that an immune response against GBS- and MFS-associated C. jejuni LPS results in antiganglioside antibodies. These results provide strong support for molecular mimicry as a mechanism in the induction of antiganglioside antibodies following infections.

* Corresponding author. Mailing address: Department of Neurology, Erasmus University Rotterdam, P.O. Box 1738, 3000 DR Rotterdam, The Netherlands. Phone: 31.10.408.8209. Fax: 31.10.408.9452. E-mail: ANG{at}neuro.fgg.eur.nl.

Infection and Immunity, April 2001, p. 2462-2469, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2462-2469.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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