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Infection and Immunity, April 2001, p. 2743-2747, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2743-2747.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Evidence of Involvement of the Mannose Receptor in Adhesion of Borrelia burgdorferi to Monocyte/Macrophages

Marina Cinco,1,* Barbara Cini,1 Rossella Murgia,1 Gianni Presani,2 Mario Prodan,2 and Sandra Perticarari2

Dipartimento di Scienze Biomediche, Università di Trieste,1 and Laboratorio di Analisi Cliniche, IRCCS, "Burlo Garofolo,"2 Trieste, Italy

Received 18 September 2000/Returned for modification 10 November 2000/Accepted 14 December 2000

The mannose receptor (MR) plays an important role in the recognition of some pathogens in nonopsonic phagocytosis and in antigen presentation to T cells. We found that Borrelia burgdorferi, the agent of Lyme borreliosis, adheres to monocyte-derived macrophages and to rat MR-transfected cells but not to untransfected cells. Antibodies to MR and sugars such as mannose, mannan, fucose, and some lectins significantly lowered the adhesion, confirming participation of the MR in the binding.

* Corresponding author. Mailing address: Dipartimento di Scienze Biomediche, Università di Trieste, 34127 Trieste, Italy. Phone: 39 40 676 7178. Fax: 39 40 351668. E-mail: cinco{at}DSBMAIL.UNITS.it.

Infection and Immunity, April 2001, p. 2743-2747, Vol. 69, No. 4
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.4.2743-2747.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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