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Infection and Immunity, May 2001, p. 2808-2814, Vol. 69, No. 5
Microbiology Section, Department of
Experimental Medicine and Biochemical Sciences, University of
Perugia, 06122 Perugia, Italy,1 and
Department of Chemistry, Georgia State University, Atlanta,
Georgia 303032
Received 2 October 2000/Returned for modification 11 November
2000/Accepted 31 January 2001
Our previous observations showed that mannoprotein (MP) induces
early and massive production of interleukin-12 (IL-12) in vitro. This
study was designed to investigate whether this phenomenon could be
applied in vivo and to determine the biological significance of MP in
Cryptococcus neoformans infection. The results reported here show that MP treatment induces IL-12 secretion by splenic macrophages and IL-12 p40 mRNA in the brain. During C. neoformans infection, MP reinforced IL-12 and IFN-
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.5.2808-2814.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
Role of Mannoprotein in Induction and Regulation of
Immunity to Cryptococcus neoformans
secretion
that coincided with enhanced antifungal activity of natural effector
cells, early resolution of the inflammatory process, and clearance of
fungal load from the brain. These studies show that MP is a key
inflammatory mediator that induces a protective immune response against
C. neoformans infection. This information can be used to
facilitate the design of a rational approach to manipulate the immune
response to C. neoformans.
*
Corresponding author. Mailing address: Microbiology
Section, Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy. Phone:
39-075-585-7407. Fax: 39-075-585-7403. E-mail:
vecchiar{at}unipg.it.
Infection and Immunity, May 2001, p. 2808-2814, Vol. 69, No. 5
0019-9567/01/$04.00+0 DOI: 10.1128/IAI.69.5.2808-2814.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.
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