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Infection and Immunity, May 2001, p. 3004-3012, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3004-3012.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

In Vivo-Expressed Genes of Pasteurella multocida

Meredith L. Hunt, David J. Boucher, John D. Boyce, and Ben Adler*

Bacterial Pathogenesis Research Group, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia

Received 20 October 2000/Returned for modification 21 December 2000/Accepted 14 February 2001

Pasteurella multocida is the causative agent of infectious diseases of economic importance such as fowl cholera, bovine hemorrhagic septicemia, and porcine atrophic rhinitis. However, knowledge of the molecular mechanisms and determinants that P. multocida requires for virulence and pathogenicity is still limited. To address this issue, we developed a genetic expression system, based on the in vivo expression technology approach first described by Mahan et al. (Science 259:686-688, 1993), to identify in vivo-expressed genes of P. multocida. Numerous genes, such as those encoding outer membrane lipoproteins, metabolic and biosynthetic enzymes, and a number of hypothetical proteins, were identified. These may prove to be useful targets for attenuating mutation and/or warrant further investigation for their roles in immunity and/or pathogenesis.

* Corresponding author. Mailing address: Bacterial Pathogenesis Research Group, Department of Microbiology, Monash University, Clayton, Victoria 3800, Australia. Phone: 61 03 9905 4815. Fax: 61 03 9905 4811. E-mail: Ben.Adler{at}med.monash.edu.au.

Infection and Immunity, May 2001, p. 3004-3012, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3004-3012.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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