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Infection and Immunity, May 2001, p. 3451-3454, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3451-3454.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Chlamydia trachomatis Infection Does Not Enhance Local Cellular Immunity against Concurrent Candida Vaginal Infection

Kathleen A. Kelly,1 Heather L. Gray,2 Jennifer C. Walker,2 Roger G. Rank,2 Floyd L. Wormley Jr.,3 and Paul L. Fidel Jr.3,*

Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, California1; Department of Microbiology and Immunology, University of Arkansas for Medical Sciences, Little Rock, Arkansas2; and Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, New Orleans, Louisiana3

Received 14 December 2000/Returned for modification 23 January 2001/Accepted 6 February 2001

Although Th1-type cell-mediated immunity (CMI) is the predominant host defense mechanism against mucosal Candida albicans infection, CMI against a vaginal C. albicans infection in mice is limited at the vaginal mucosa despite a strong Candida-specific Th1-type response in the draining lymph nodes. In contrast, Th1-type CMI is highly effective against an experimental Chlamydia trachomatis genital tract infection. This study demonstrated through two independent designs that a concurrent Candida and Chlamydia infection could not accelerate or modulate the anti-Candida CMI response. Together, these results suggest that host responses to these genital tract infections are independent and not influenced by the presence of the other.

* Corresponding author. Mailing address: Department of Microbiology, Immunology, and Parasitology, Louisiana State University Health Sciences Center, 1901 Perdido St., New Orleans, LA 70112-1393. Phone and fax: (504) 568-4066. E-mail: pfidel{at}lsuhsc.edu.

Infection and Immunity, May 2001, p. 3451-3454, Vol. 69, No. 5
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.5.3451-3454.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


This article has been cited by other articles:

  • LeBlanc, D. M., Barousse, M. M., Fidel, P. L. Jr. (2006). Role for Dendritic Cells in Immunoregulation during Experimental Vaginal Candidiasis.. Infect. Immun. 74: 3213-3221 [Abstract] [Full Text]  
  • Wormley, F. L. Jr., Chaiban, J., Fidel, P. L. Jr. (2001). Cell Adhesion Molecule and Lymphocyte Activation Marker Expression during Experimental Vaginal Candidiasis. Infect. Immun. 69: 5072-5079 [Abstract] [Full Text]  


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