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Infection and Immunity, June 2001, p. 4103-4108, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4103-4108.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.

Protection against Cutaneous Leishmaniasis Induced by Recombinant Antigens in Murine and Nonhuman Primate Models of the Human Disease

Antonio Campos-Neto,1,2,* Renato Porrozzi,3 Kay Greeson,1 Rhea N. Coler,1 John R. Webb,4 Yasir A. W. Seiky,5 Steven G. Reed,1,5 and Gabriel Grimaldi Jr.3

Infectious Disease Research Institute1 and Corixa Corporation,5 Seattle, Washington 98104; Medical School of Itajubá, Itajubá MG,2 and Instituto Oswaldo Cruz, Rio de Janeiro RJ,3 Brazil; and Faculty of Medicine, University of Ottawa, Ottawa, Canada4

Received 18 August 2000/Returned for modification 4 October 2000/Accepted 6 March 2001

Leishmaniasis affects approximately 2 million people each year throughout the world. This high incidence is due in part to the lack of an efficacious vaccine. We present evidence that the recombinant leishmanial antigens LmSTI1 and TSA, which we identified and characterized previously, induce excellent protection in both murine and nonhuman primate (rhesus monkey) models of human cutaneous leishmaniasis. The remarkable protection induced by LmSTI1 and TSA in an animal model that is evolutionarily close to humans qualifies this antigen combination as a promising candidate subunit vaccine against human leishmaniasis.

* Corresponding author. Mailing address: Infectious Disease Research Institute, 1124 Columbia St., Suite 600, Seattle, WA 98104. Phone: (206) 381-0883. Fax: (206) 381-3678. E-mail: acampos{at}idri.org.

Infection and Immunity, June 2001, p. 4103-4108, Vol. 69, No. 6
0019-9567/01/$04.00+0   DOI: 10.1128/IAI.69.6.4103-4108.2001
Copyright © 2001, American Society for Microbiology. All rights reserved.


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